Mental Illness

Download Neurogenetics of psychiatric disorders by Akira Sawa, Melvin G. McIinnis PDF

By Akira Sawa, Melvin G. McIinnis

Translating bench-based learn into potent medical perform, this resource presents a transparent knowing of the neurobiology and neurogenetics of psychiatric issues, the genes accountable for particular psychiatric issues, and the consequences of genetic roots and underlying biology at the improvement of recent diagnostic ways and remedy remedies for numerous psychiatric stipulations.

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This “model-free” approach also enables recruitment of a wider array of multiply affected families. 2-q25 (18,19), and 22q12-q13 (20,21). , 6p22-p24, 6q13q26, 10p15-p11, 13q32, and 22q12-q13), many other samples have failed to detect linkage in these regions (22–26) (27) (21) (28). The lack of overlap may be due to false-positive results or genetic heterogeneity (the possibility that several genomic regions may harbor genetic risk factors for the same disorder). Efforts are in progress to synthesize these data.

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Ertekin-Taner N, Graff-Radford N, Younkin LH, et al. Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer’s disease pedigrees. Science 2000; 290:2303–2304. 65. Bertram L, Blacker D, Mullin K, et al. Evidence for genetic linkage of Alzheimer’s disease to chromosome 10q. Science 2000; 290:2302–2303. 66. Ropacki SA, Jeste DV. Epidemiology of and risk factors for psychosis of Alzheimer’s disease: a review of 55 studies published from 1990 to 2003. Am J Psychiatry 2005; 162:2022–2030.

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