Internal Medicine

Download Human placental trophoblasts : impact of maternal nutrition by Asim K. Duttaroy, Sanjay Basak PDF

By Asim K. Duttaroy, Sanjay Basak

Human Placental Trophoblasts: effect of Maternal Nutrition

explores the important roles of trophoblasts play in fetal development and being pregnant, supplying you with new perception into the modulation of placental trophoblast features via nutrition. It additionally stories the function of fatty acids, folic acids, and particular supplementations during this point. The ebook highlights the severe position of nutrition on human placental improvement and its' in utero programming results at the improvement of power ailments corresponding to sort 2 diabetes, cardiovascular illnesses, high blood pressure, and weight problems in later life.

The booklet starts off with discussions of the crucial technique of placentation and its legislation on dimension and development of the fetus. It additionally covers the consequences of key macronutrients on placental progress, metabolism, delivery, and secretory functionality. The textual content info very important supplements and few micronutrients and their roles within the feto-placental development and improvement. It contains details at the impression of maternal way of life and environmental components on rules of the expansion, metabolism and gene expression within the feto-placental unit. A evaluation of the genes associated with the method of placentation rounds out the coverage.

An exam of a vast diversity of facts within the parts of placental development, functionality, and its influence on feto-placental consequence, the publication provides new wisdom on nutrients and its relevance with early human improvement. This contains not just the results of maternal nutrition on attainable neonatal progress and improvement but in addition their legislation by way of maternal way of life linked components. a good mixing of epidemiology, medical meals, perinatal and neonatal drugs, and biochemistry and molecular biology components of analysis actions, the ebook permits you to comprehend the impression of maternal food on placentation and its relevance with being pregnant end result and fetal programming of grownup healthiness and disease.

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Additional info for Human placental trophoblasts : impact of maternal nutrition

Example text

However, also the pressure of the uterine venous system affects the intervillous pressure. The regulation of the pressure within the villous capillaries has also been the subject of considerations but remains an elusive topic. It is conceivable that pressure disturbances in the pressure gradient across the vasculo-syncytial layer may underlie certain kinds of disturbed villous development, including avascular villi, with or without fibrinoid deposition and cases of impaired maturation. Another hemodynamic variable that may affect the development of the villous capillaries is the speed of the fetoplacental blood flow through changes in the sheer stress against the endothelial surface.

Ultrastructure of the normal human placenta. Electron Microscopy Reviews 4 (1): 129–178. Kaufmann P, Huppertz B, and Frank HG. 1996. The fibrinoids of the human placenta: Origin, composition and functional relevance. Annals of Anatomy 178 (6): 485–501. Kingdom J, Huppertz B, Seaward G, and Kaufmann P. 2000. Development of the placental villous tree and its consequences for fetal growth. European Journal of Obstetrics, Gynecology, and Reproductive Biology 92 (1): 35–43. Lager S and Powell TL. 2012.

Lievano S, Alarcon L, Chavez-Munguia B, and Gonzalez-Mariscal L. 2006. Endothelia of term human placentae display diminished expression of tight junction proteins during preeclampsia. Cell and Tissue Research 324 (3): 433–448. Lyall F, Bulmer JN, Duffie E, Cousins F, Theriault A, and Robson SC. 2001. Human trophoblast invasion and spiral artery transformation: The role of PECAM-1 in normal pregnancy, preeclampsia, and fetal growth restriction. American Journal of Pathology 158 (5): 1713–1721. Lynge NL, Djurisic S, and Hviid TV.

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