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By P. Palange, S. Ward

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Oxygen Uptake Kinetics in Health and Disease. Routledge Publs, London, 2004. J. WHIPP ET AL. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. 69. Shinohara M, Moritani T. Increase in neuromuscular activity and O2 uptake during heavy exercise. Ann Physiol Anthrop 1992; 11: 257–262. Bearden SE, Moffatt RJ. V9O2 and heart rate kinetics in cycling: transitions from an elevated baseline. J Appl Physiol 2001; 90: 2081–2087. Russell A, Wadley G, Snow R, et al. Slow component of V9O2 kinetics: the effect of training status, fibre type, UCP3 mRNA and citrate synthase activity.

The legs (largely) for cycle ergometry. g. A. 0 Fig. 1. – Periodic oscillations in carbon dioxide output (V’CO2; - - - -), oxygen uptake (V’O2; – – – –) and minute ventilation (V’E; ––––), during incremental exercise in a patient with heart failure. Reproduced from [14] with permission. g. kg-1 body mass at constant pedalling frequency (fig. 2) [5, 15]. This would be expected to impose an upward shift of the V’O2,–WR relationship, resulting in an increased oxygen cost at a given WR (fig. 3). Cycle ergometers with a substantial ‘‘unloaded’’ pedalling setting will also induce higher-than-normal V’O2,BL responses.

Whatever the aetiology of these various DV’O2/DWR abnormalities, it cannot be emphasised enough that meaningful interpretation of purported changes in DV’O2/DWR requires that the slope estimation be conducted over a WR region for which the V’O2–WR WR Fig. 5. – Schematic diagram of the oxygen uptake (V’O2)–work rate (WR) relationship for ramp-incremental exercise showing the response for a subject of poor fitness (slow kinetics, low peak V’O2: – – – –) with a restricted linear phase, relative to normal (—–).

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