Internal Medicine

Download Acute and Chronic Cough by Anthony E. Redington, Alyn H. Morice PDF

By Anthony E. Redington, Alyn H. Morice

A entire overview of the medical and scientific elements of acute and persistent cough, this reference specializes in contemporary advancements in our figuring out of the molecular biology of putative cough receptors, the neural mechanisms taken with the afferent and efferent limbs, the vital processing of the cough reflex, and peptides and different elements which could mediate or modulate the cough reflex. With chapters written through said specialists within the box, this instruction manual covers present and strength healing brokers, quite a few methodologies to degree cough reflex sensitivity, and scientific methods for the evaluation of persistent cough in adults and youngsters.

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Saitou N, Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 1987; 4:406–425. 20. Clapham DE, Runnels LW, Strubing C. The TRP ion channel family. Nat Rev Neurosci 2001; 2:387–396. 21. Montell C. Physiology, phylogeny, and functions of the TRP superfamily of cation channels. Sci STKE 2001; 2001:RE1. 22. Kress M, Zeilhofer HU. Capsaicin, protons and heat: new excitement about nociceptors. Trends Pharmacol Sci 1999; 20:112–118. 23. Welch JM, Simon SA, Reinhart PH.

Various putative functions in each region have been suggested. Although its role in these tissues remains to be fully defined, the function of TRPV1 may not show marked discrepancy with its originally characterized role (89,90,92,93). A valuable future approach may be to investigate possible functions of TRPV1 in the central nervous system from a viewpoint that considers its relationship with endogenous ligand candidates such as NADA. Despite the lack of data from jugular ganglia, it is reasonably certain that TRPV1 is significantly expressed in vagal afferent projecting to the airways.

Trends Pharmacol Sci 1998; 19:460–466. 3. Joos GF, Germonpre PR, Pauwels RA. Neural mechanisms in asthma. Clin Exp Allergy 2000; 30(suppl 1):60–65. 4. Fields HL. Pain. New York: McGraw-Hill, 1987. 5. Karlsson JA. The role of capsaicin-sensitive C-fibre afferent nerves in the cough reflex. Pulm Pharmacol 1996; 9:315–321. 16 Hwang 6. Canning BJ. Interactions between vagal afferent nerve subtypes mediating cough. Pulm Pharmacol Ther 2002; 15:187–192. 7. Hwang SW, Oh U. Hot channels in airways: pharmacology of the vanilloid receptor.

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